A new approach for modeling prokaryotic biochemical networks with differential equations

Gebert, Jutta and Radde, Nicole (2006) A new approach for modeling prokaryotic biochemical networks with differential equations.
Published In: Computing anticipatory systems : CASYS'05 - seventh international conference ; held in Liege, Belgium, 8 - 13 August 2005 AIP 2006, pp. 526-533.

Abstract

One major challenge in Computational Biology is the simulation of the processes in a biological cell, which makes it necessary to understand the interactions between cell components. It is convenient to model the entirety of such interactions as biochemical networks. In this paper we present our novel approach to describe these biochemical networks with piecewise linear differential equations and analyze it theoretically. Then we will discuss methods for the parameter estimation from time series measurements including inference of the network topology. Finally we show an application of our model for the bacterium {it Corynebacterium glutamicum}.


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Deposit Information:
ZAIK Number: zaik2007-554
Depositing User: Nicole Radde
Date Deposited: 22 Jun 2007 00:00
Last Modified: 11 Aug 2011 16:30
URI: http://e-archive.informatik.uni-koeln.de/id/eprint/554